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Villanueva and his team clued into a different outlook on cold adaptation after determining that circulating levels of a waxy lipid called acylcarnitines fluctuated in response to the cold

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Furthermore, quantification of hepatocellular vacuolation (a characteristic of cellular degeneration observed through tissue pathology staining) at the 2-h time point revealed a 1.5-fold greater area of liver degeneration in hepsin / mice compared with wild-type mice, which increased to ~ 2.5-fold greater by the 6-h time point (Fig