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Orforglipron wedges into the transmembrane domain specifically the hydrophobic pocket around tryptophan-33 in the receptor's helical bundle and preferentially activates the Gs proteincoupled cyclic AMP signaling pathway while minimally recruiting -arrestin, the protein responsible for receptor internalization and desensitization

Two names rule the discussion: Semaglutide (Ozempic, Wegovy) and Tirzepatide (Mounjaro)

Simultaneously, GLP-1 receptor activation stimulates glucose-dependent insulin release from pancreatic beta cells, suppresses inappropriate glucagon secretion, slows gastric emptying, and promotes satiety through central nervous system pathways

Food 19 (8), 717729 (2016)

Consider EEG monitoring in patients with a seizure disorder or history of seizures, or in those who experience myoclonic movements, twitching, or show evidence of focal seizures