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6), modulating their cytosolic positioning and function

In nutrient-rich conditions, mTOR remains active, suppressing autophagy initiation, while under stress conditions such as energy deficiency or DNA damage, the activation of AMP-activated protein kinase (AMPK), p53 or inhibition of pathways like PI3K/Akt and ERK reduces mTOR activity, which then releases the inhibition on autophagy and facilitates its initiation (Yang and Klionsky, 2010)

doi: 10.3390/jcm9123941 [DOI] [PMC free article] [PubMed] [Google Scholar] 251

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