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More importantly, our results showed elevated histamine-filled MCs in the human ischemic brain during the acute and sub-acute phase of stroke, whereas in chronic stroke, MC were devoid of granules suggesting an early response of histamine in the activation of pro-inflammatory signals after stroke

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Key molecular mechanisms include ROS-mediated MAPK phosphorylation [375], triggering NLRP3 inflammasome assembly [376], oxidative modification of NF-B inhibitor proteins leading to their nuclear translocation [377], and induction of mitochondrial DNA mutations [378]

doi: 10.1016/j.bbrc.2012.11.103

In the nucleus, they function along with other coactivators to initiate the transcription of target genes under certain stimuli, such as oxidative stress, disrupting binding (Baird and Yamamoto, 2020)