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In animal models of diet-induced obesity, treatment with the peptide prevented the development of insulin resistance and hyperinsulinemia

It adds that the split between fat and water only becomes clear after four to eight weeks of consistent treatment, which is another reason not to read too much into week one

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Further analyses of differentially expressed genes between GLP-1MK-801 and semaglutide treatment groups support this notion by showing enrichment of functional terms pertaining to glutamatergic signalling and synaptic plasticity among the most upregulated genes