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Because this side effect occurs consistently, it has led to interest in topiramate for obesity, but the risks associated with the drug make off-label use for weight loss inappropriate outside specialist settings
Besides the relationship between linc00336/miR-6852 and lncRNA P53rra/G3BP1 mentioned above, lncRNAs modulate ferroptosis indirectly by targeting ferroptosis-associated factors (Table 2)
Cell Culture The human hepatoma HepG2 cell line was provided by the RIKEN BRC through the National Bio-Resource Project of the MEXT, Japan, and 3T3L1 cells were purchased from the Japanese Cancer Research Resources Bank
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If HbA1c targets are not met after an adequate trial, treatment should be reviewed and intensified in line with agreed individual targets and NICE guidance
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