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Folate, homocysteine, interleukin-6, and tumor necrosis factor alfa levels, but not the methylenetetrahydrofolate reductase C677T Polymorphism, are risk factors for schizophrenia

DN related to ferroptosis mainly manifests as oxidative stress, lipid peroxidation, and iron homeostasis disorders [229, 230]

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Clearly, SAMes cellular functions are of direct relevance to the prevention of neurodegeneration and its depletion, as seen in the AD central nervous system, would be expected to carry widespread deleterious sequelae