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While trials used 6 mg, 12 mg, and 36 mg doses, Lilly conducted pharmacokinetic studies to establish equivalent doses of 9 mg, 14.5 mg, and 17.2 mg for manufacturing

A treatment-related increase in malignant thyroid C-cell carcinomas was observed in all male liraglutide-treated groups with incidences of 2%, 8%, 6%, and 14% and in females at 0.25 and 0.75 mg/kg/day with incidences of 0%, 0%, 4%, and 6% in 0 (control), 0.075, 0.25, and 0.75 mg/kg/day groups, respectively

McLeod provided Banting with laboratory facilities, some experimental dogs and the assistance of Charles Best, a research student

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