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Animal experiments and studies of human subjects have shown that IOP-independent factors include oxidative stress, glutamate excitotoxicity, and impaired retinal blood flow 6,7,8

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p38 MAPK activation is a major component deciding cell fate in response to cisplatin, primarily to induce apoptosis (Brozovic and Osmak, In animals exposed to intense noise, MAPK phosphorylation in the cochlea is altered, ERK1/2 in the sensory and support cells of the cochlear sensory epithelium are activated by phosphorylation

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