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Thermal Degradation Temperature fluctuations during storage and shipping can accelerate chemical breakdown in sensitive APIs

doi: 10.1016/S0149-2918(98)80104-5 176 KaleagasiogluFOlcayE

[DOI] [PubMed] [Google Scholar] 5.Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum

It also improves insulin sensitivity, which can benefit individuals with type 2 diabetes

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In the gastrointestinal tract, current studies have identified that metformin effects glucose uptake and absorption, influences GLP-1 secretion, modulates immune homeostasis, and regulates the gut microbiota, detailed information was drawn in Figure 1