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This is a significant quality-of-life outcome, as CPAP adherence is a persistent challenge, studies estimate that 30 to 50 percent of patients prescribed CPAP do not use it consistently

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462,476 Early structural work on Bs MntR revealed that the metal-binding pocket was substantially distinct from that of DtxR, with the two metal binding sites physically closer, sharing two bridging ligands, and including two water molecules, allow for heptacoordination of the Mn II ions (Figure 15C)