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Lifestyle changes remain essential

While a number of mechanisms including vascular, myocardial, renal, and central nervous system pathways have been suggested in animal studies, these mechanistic pathways have not been sufficiently detailed in humans and it is unclear if the same pathways are operational

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Area under the curve (AUC) and C max were not significantly affected by L-carnitine (Fig

although, oral supplementation with L-citrulline, a precursor for arginine biosynthesis, has been shown to be more efficient than oral L-arginine in increasing plasma L-arginine [9], due to splanchnic catabolism of ingested L-Arginine [24]