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Notably, PAC is a particular NSAIDs with no or negligible anti-inflammatory and antiplatelet activity (Driver et al., 2019)

In an RCT of 44 youth assigned to lithium only or lithium + tamoxifen 2040 mg, the augmentation with tamoxifen group had significantly more 50% reduction proportion in the active treatment augmentation group for mania ratings compared to placebo augmentation (Fallah et al., 2016)

Vitamin C and vitamin E both require glutathione to return to their active forms after neutralizing free radicals

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This has opened new avenues for treatment, offering hope for improved management of chronic diseases