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The effect of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) severity on cellular bioenergetic function

Die Bestimmung des GSH/GSSG-Quotienten im Serum wird heute kaum noch durchgefhrt, da die Ergebnisse keinen Rckschluss auf die entscheidenden intrazellulren Verhltnisse zulassen

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109 Additionally, metabolites such as 2-hydroxyglutarate, succinate, and fumarate derived from mutations in IDH1/2, FH, and SDH inhibit DNA repair pathways by repressing lysine demethylase KDM4B, resulting in abnormal excessive H3K9 methylation at DNA break sites, impairing recruitment of TIP60 and ATM, reducing end resection, and decreasing recruitment of downstream repair factors