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Full article: Diabetes, Obesity and Metabolism DOI: 10.1111/dom.70572 I would value your perspective

Co-treatment of 4d (A2-thio-imidazole derivative), a novel TGR5 agonist, and Sitagliptin (DPP-4 inhibitor) exhibited a GLP-1 secretion and glucose-lowering effect in animal models, while this compound alone exhibits only a slight 1.3-fold increase in GLP-1 secretion [182]

If successful, future work investigating the combination of an SGLT2i with a dual continuous glucose and ketone sensor may allow individuals with type 1 diabetes to access SGLT2i therapy

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The Physiological Roles of Incretin Hormones Food intake stimulates the postprandial release of incretin hormones, particularly GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), from enteroendocrine cells located in the epithelial mucosa of the small intestine

Insulin signaling impairment in the brain as a risk factor in Alzheimers disease