Some harmful effects of hypercorticoidism, which can culminate with aging-related diseases, are deleterious effects on the central nervous system (CNS), including neuroinflammatory environment, loss of neuronal function, and apoptosis of neuronal cells, causing a decrease in hippocampal neurogenesis and an increase in neuroinflammation and neurodegeneration [4244]
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Nausea, constipation, and decreased appetite are most common, particularly during dose titration
[DOI] [PubMed] [Google Scholar] 29.Effect of low-dose selenium on thyroid autoimmunity and thyroid function in UK pregnant women with mild-to-moderate iodine deficiency
Metabolism and disposition of intravenously administered acetyl-L-carnitine in healthy volunteers
References Sheer AJ, Donahoo WT, Johnson-Mann CN