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Our group has recently invented a molecular combination (cARLA) synergistically targeting signaling pathways related to BBB maturation that elevated the barrier tightness and other BBB-specific properties in several BBB culture models including human stem cell-based ones [40]

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In 1966, based on the viscosity measurements for a set of 12 proteins unfolded in 56 M GdmCl, Charles Tanford (19212009), Kazuo Kawahara, and Savo Lapanje (19251997) concluded that unfolded proteins demonstrate random coil behavior (Tanford et al., 1966)