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Sandborn WJ, Ghosh S, Panes J, Vranic I, Wang W, Niezychowski W, et al

With regard to depression, we have few and inconclusive studies, although we would like to point out that one study on patients with a major depressive episode, who had a chronic psychiatric disorder (on average, for almost 17 years) and therefore had a poor response to pharmacological treatment, concluded that supplementing standard treatment with NAC has favorable effects by reducing symptoms and improving patients functioning [129]

Two things floating around online that cause fear-mongering: There's one scary-sounding study related to kidney tumors in male rats

doi: 10.21856/j-PEP.2020.1.03 198 KalachevaAGromovaOGrishinaTBogachevaTDemidovVTorshinIYet al

[7] [9] The injection should not be administered to patients with severe hypersensitivity reactions to preservatives, if using the preserved formulation

Clinical data shows 46 pounds lost for a 220 lb person