CoveyDFNathanDKalkbrennerMNilssonKRHuYZorumskiCFet al
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One practical consideration: antibiotics can worsen GI symptoms in some people, and if you are already dealing with semaglutide-related nausea or diarrhea, this overlap can be uncomfortable
If the efficacy readouts from SURMOUNT-1 are reproducible, Lilly almost certainly has a best-in-class medication this may be plainly reflected in the SURMOUNT-5 Phase 3b trial readout (1H 2025)
Yes clinical trial data shows cagrilintide has a higher incidence (4060%) and greater severity of nausea compared to semaglutide (3045%) or tirzepatide (2535%)
However, this is considered an underestimation as it will be unlikely to be detected in smaller clinical trials, and a more recent study in 2010 found that NSAIDs including ibuprofen (odds ratio of 2.24, 95% confidence interval (CI) = 1.992.52) increased the risk of hospitalization due to acute hepatitis (odds ratio 2.13, 95% CI = 22.18) 35
