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In the UK, NICE guidance (NG28) recommends considering GLP-1 receptor agonists for patients with type 2 diabetes according to specific criteria, typically when treatment with metformin and other oral medications has not achieved adequate glycaemic control

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These findings suggest that SCFAs, BAs, and tryptophan metabolites may form an interlinked metabolic network that collectively shapes immune responses in the gut and potentially at distal sites such as the eye

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