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Thinning and shedding can have a wide range of causes, including genetics, illness, hormonal imbalance, stress, pregnancy, diet, alopecia areata and lifestyle

Upregulation of TXNIP by ROS stimulated the NLRP3 inflammasome, which activated the protease caspase-1 to facilitate the release of inflammatory cytokines such as interleukin-18 (IL-18) and interleukin-1 (IL-1) and triggered inflammatory responses

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