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According to a 2024 poll , one in eight adults has at least tried this medication class

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In the CNS, IL-1 and IL-6 were demonstrated to mediate GLP-1 receptor-induced suppression of food intake, and body weight (109)

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To reduce the risk of side effects and any adverse events from GLP-1 medications, here are some guidelines to keep in mind: Start with a low dose and gradually increase the dose over time Take the medication with meals Eat smaller, more frequent meals Stay well-hydrated Avoid fatty, spicy, or smelly foods if they exacerbate symptoms Consider anti-nausea medications if needed For constipation: Use fiber-rich foods (and over-the-counter laxatives) if needed for constipation Use proper injection technique and rotate injection sites Monitor blood glucose levels regularly, especially if taking other diabetes medications Allergic reactions Although rare, allergic reactions to GLP-1 agonists can occur

Retatrutide is still an investigational drug and long-term trials are still on the way