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In the chronic stress studies, caffeine was administered chronically but with variation in time of exposure in two [28], three [29], four [30], or six weeks [31]

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Despite limited investigation of sex and other biological variables potentially influencing ketamines opioid-dependent therapeutic efficacy, preliminary preclinical work suggests subanesthetic ketamine evokes opioid-mediated behavioral and neurophysiological effects in male but not female rats 46