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Importantly, a GLP-1 receptor antagonist blocked these response patterns, supporting the idea that these effects were indeed mediated by GLP-1 receptors (ten Kulve et al., 2017)

This is particularly beneficial for individuals whose bodies may not absorb or synthesize enough L-carnitine naturally, such as those with certain genetic disorders, older adults, or individuals undergoing specific medical treatments that decrease carnitine absorption or increase its excretion

Change from baseline in circulating lipids Decreases in total cholesterol, LDL, very low-density lipoprotein (VLDL), and triglyceride were observed with all orforglipron doses in the T2D trial (Fig