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TOPI inhibitor-induced SSBs require tyrosyl-DNA phosphodiesterase 1 (TDP1)-mediated excision repair and homologous recombination pathways for repair, so mCRPC tumors harboring HRD may exhibit increased sensitivity to TOPI inhibitor-carrying ADCs 36,37

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Some aggressive community protocols use weight-based dosing from the original mouse study: The community weight-based protocol uses the direct mg/kg number from mice without allometric correction

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