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Additionally, the inhibition of N-glycosylation, which is essential for the membrane localization and interaction of CD98hc with xCT, enhances the sensitivity of PDAC cells to ferroptosis

We will discuss the biological mechanisms underlying the observed benefits, results from clinical studies (RCTs and prospective studies) regarding disease-free survival (DFS), overall survival (OS), quality of life (QoL), and side effects, proposed exercise protocols, and strategies to integrate this evidence into clinical practice (Figure 1)

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Gdh3 favours the assimilation of ammonium through the anabolic reaction with -ketoglutarate to form glutamate