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Improved sleep quality is typically the first benefit patients notice, usually within the first one to two weeks

A similar finding was observed in the elevated plus maze (EPM) test (Supplementary Fig

The dose is usually administered on the same day each week, following a gradual dose-escalation schedule determined by the clinical trial protocol

Other barriers to weight loss include lifestyle habits, such as not exercising or routinely eating sugary or fatty foods, and medication adherence

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All the statistical analyses were performed in GraphPad Prism 9 and were specified in each figure legend