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As an effect of ROS on the central nervous system (CNS), which has a high lipid content and high oxygen consumption, the oxidative agents promote lipid peroxidation, leading to membrane fluid loss, suppressing membrane potential, and increasing the accumulation of ions, particularly Ca 2+
Meanwhile, elamipretide acts by binding to cardiolipin, stabilizing the, ETC., supercomplexes, and reducing electron leakage, thereby decreasing mtROS production at its source (Deng et al., 2023
Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Ethanol : 70 mg/mL (Need ultrasonic) In Vivo : Select the appropriate dissolution method based on your experimental animal and administration route
With RI at 10 mg the induction was in GST activity
Glutathione is often called the master antioxidant
