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This pulsatile pattern is central to GH biology and is shaped by GHRH, somatostatin, ghrelin, sleep, age, and metabolic state. One important finding from CJC-1295 with DAC research is that GH secretion remained pulsatile even during prolonged GHRH analog stimulation. This helps distinguish GHRH analogs from direct GH replacement, which bypasses upstream pituitary signaling

Thakker D, et al

Endocrine dysfunction in Prader-Willi syndrome: a review with special reference to GH

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