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In addition to damaging lipids, large amounts of ROS disrupt endoplasmic reticulum homeostasis and lead to the accumulation of misfolded and unfolded proteins, activating unfolded protein responses and triggering endoplasmic reticulum stress (ERS) [85]

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The researchers also suggested that ASS negativity is a potential prognostic biomarker for HCC (207)

In addition, the toxicity of the synthesized nanocarriers with a certain amount of drug was evaluated using an MTT assay

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