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EV-derived VDAC1 protein activates autophagy by modulating AMPK/mTOR/p70S6K signaling to spread PTX resistance of GC cells Intracellular ATP levels were measured to further explore the specific pathways through which VDAC1 regulates autophagy

The saturation dose principle Research has established that the optimal single dose of GHRP-6 is approximately 1 mcg per kilogram of body weight

Assessing GSH status is critical for studying oxidative stress mechanisms and downstream effects of oxidative damage

Formononetin attenuates renal tubular injury and mitochondrial damage in diabetic nephropathy partly via regulating sirt1/PGC-1 pathway

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When stratified by comparator groups, the pooled estimate was most favorable in monotherapy trials versus placebo (SMD 2.41, 95% CI 4.43 to 0.39), whereas the add-on designs versus the same background treatment (SMD 0.65, 95% CI 1.85 to 0.55), head-to-head comparisons versus another drug (SMD 0.19, 95% CI 0.84 to 0.45), and add-on designs versus placebo (SMD 0.65, 95% CI 1.35 to 0.06) showed more modest estimates and did not provide clear evidence of a between-group difference overall (p=0.21)