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With a high cell-energy charge within hepatocytes, co-enzyme A (CoA) exists principally as acetyl-CoA which potently activates pyruvate carboxylase, directing pyruvate toward gluconeogenesis

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Though the mean survival against arsenite treatment for the majority of the silenced GST genes showed a modest decrease, the knockdown of only gst-32 and gst-44 significantly decreased survival [57]

Review: chemical pathology of homocysteine VI

10.1038/sj.cdd.4402280 Cell Death

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