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2011), results in a slow process of healing, particularly when addressing complete ruptures, which often require surgery

Currently, in the recruitment phase as of 2024, REDEFINE-3 will use a dosing schedule similar to other REDEFINE and REIMAGINE trials

While individual comfort levels vary, B12 injections are easily tolerated by most patients

High-dose oral therapy (10002000 micrograms daily) can effectively treat deficiency even in those with impaired intrinsic factor-mediated absorption, relying on passive diffusion

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The trial was registered at irct.ir website (IRCT20120718010333N5)