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p62 activators Two compounds able to increase p62 levels, trehalose and rapamycin, have been demonstrated to increase nuclear translocation of NRF2 in a p62-dependent manner and to enhance expression of its downstream antioxidant factors, HO1 and NQO1, in a hepatoma cellular system [308] and in a preclinical model of FRDA [309]

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It is naturally present in human plasma, saliva, and urine, and plays a proposed role in tissue maintenance and repair signalling

Inflammatory response of disc cells against Propionibacterium acnes depends on the presence of lumbar Modic changes

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