While Alnylams Phase III APOLLO-B study hit both key primary and secondary endpoints, the FDA stated in the documents that the effects of patisiran compared to placebo on both endpoints were small, of questionable clinical meaningfulness, and may not be detectable by patients. Major discussion points during the adcomm meeting included whether these key endpoints were appropriate to ascertain clinical meaningfulness in the ATTR-CM population, and panelists expressed varying opinions on whether the magnitude of the benefit seen in trial data was clinically meaningful
Table of Contents Key Takeaways: GHK-Cu is a naturally occurring copper peptide found in human plasma, saliva, and urine
Compounded versions of this dual agonist, often labeled GLP-1 GIP B12, add a third element: vitamin B12
L-Arginine is essential for the production of nitric oxide, which helps relax and dilate blood vessels, promoting healthy circulation and reducing blood pressure
Patients should be aware of the need to have a readily available source of glucose (dextrose, d-glucose) or other carbohydrate to treat hypoglycemic episodes
The loss of postprandial glycemic control precedes stepwise deterioration of fasting with worsening diabetes
