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Retrieved June 9, 2023

For individuals following plant-based diets, fortified foods (such as breakfast cereals, plant-based milk alternatives, and yeast extracts) or supplements become essential sources

TIER PLANS TIER 1 (5mg total) $195 total for 8-10 week supply Monthly cost breakdown: $78-$97 based on weekly dose Recommended if new to treatment or for those on 0.2-0.6mg/week TIER 2 (10mg total) $230 total for 8-10 week supply Monthly cost breakdown: $92-$115 based on weekly dose Recommended for those on 0.7-1.2mg/week TIER 3 (20mg total) $260 total for 8-10 week supply Monthly cost breakdown: $104-$130 based on weekly dose Recommended for those on 1.3mg/week and up TIER 4* (30mg total) $300 total for 8-10 week supply For patients approved to be on high dose therapy of 3-4mg per week Monthly cost breakdown: $120-$150 based on weekly dose TIER 5* (40mg total) $350 total for 8-10 week supply For patients approved to be on high dose therapy of 4-5mg per week Monthly cost breakdown: $140-$175 based on weekly dose Southend Pharmacy - Semaglutide/B6 Injection Up to 90 days BUD

HSL, first cloned by Holm in 1988 (38), is the main diacylglycerol (DAG) lipase in adipocytes