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Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo

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The last sentence is odd In a separate study, no apparent effect on the rate of gastric emptying was observed with semaglutide 2.4 mg. The study isnt cited so Im not clear if they mean that no apparent effect of delayed gastric emptying on the absorption of concomitantly taken drugs was observed, or if they are saying that taking semaglutide 2.4mg did not have an effect on the rate of gastric emptying which doesnt make sense since delayed gastric emptying is a well-studied effect of the drug

The mean increase in delta activity reached approximately 35% in the neocortex and limbic cortex compared to control animals receiving cerebrospinal fluid or other peptide preparations

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