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Major adverse effect of IV acetylcysteine is: a) Hypertension b) Anaphylactoid reaction c) Bradycardia d) Constipation Answer: b) Anaphylactoid reaction 6

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(Falutz et al., NEJM, 2007) A subsequent NEJM trial by Stanley et al

Fujioka also examines oral alternatives, safety concerns, and real-world prescribing considerations