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This phenomenon is seen with highly lipophilic compounds that initially enter high blood flow tissues (e.g., brain), then redistribute to tissues (e.g., muscle or fat) with lower blood flow

J Invest Dermatol (1996) 106(5):114551

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Disruption of SAM synthesis affects cellular integrity and function

Yamamoto et al

Uchiyama, J., Akiyama, M., Hase, K., Kumagai, Y