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As cosmetic chemist Colins writes it, "its safety really is beyond any doubt"

J Dermatol Sci 106:132140 Osawa R, Akiyama M, Shimizu H (2011) Filaggrin gene defects and the risk of developing allergic disorders

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In a study on rats (0, 1.8, 3.8, 15 or 175 mg/kg body weight per day), the effects were characterized histologically as an increase in the incidence and severity of hyperplasia, hyperkeratosis, and ulcers and erosions of the squamous mucosa of the forestomach, and as epithelial hyperplasia of the kidney proximal convoluted tubules at 3.8 mg/kg and above