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While therapeutic dosing generally produces concentrations below 0.5 mol/L, values in people taking recommended dosages have been reported to be very close to the lower limit of APAP-CYS concentration associated with acetaminophen toxic overdoses (1.0 mol/L)

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It just makes the process miserable and increases the risk of discontinuation

Those results seem to hold across studies

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Molecules 2020;25:609