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The ability to shuttle between the +1, +2, and +3 oxidation states is responsible for the versatile chemistry of vitamin B 12 , allowing it to serve as a donor of deoxyadenosyl radical (radical alkyl source) and as a methyl cation equivalent (electrophilic alkyl source)

It could also be due to the adipocyte dysfunction linked to low vitamin B12 levels through cellular inflammation

A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity