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In our GBM models, depletion of the cellular NADH pool resulting from the combined treatment of sertraline and chloroquine might enhance the sensitivity of resistant GBM cells to chloroquine by increasing the availability of the NADH-binding pocket to exert its function

In the second study 36 patients with OSA and T2D were divided into 2 arms: (i) DAPA arm ( n = 18) all patients received DAPA in a daily dose of 5 mg, which was increased to 10 mg 1 week later