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By targeting specific cellular pathways, it may support fat reduction, improve energy balance, and promote overall metabolic health

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Targeted metabolomic analyses using ML have identified bile acids, ceramides, and amino acids as predictive biomarkers for T2DM development, while anthropometric features such as body mass index and waist circumference were found to have limited predictive value (160)

It is an essential part of the insulin response to what we eat: in healthy people, it is estimated that around 70% of the insulin produced by the pancreas is a consequence of the incretin effect

Acknowledgements The authors gratefully acknowledge the support and insightful feedback provided by co-workers and affiliated institutions during the preparation of this Review