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As a result, hepatic microvesicular steatosis develops, as well as hyperammonemia, anion gap acidosis, metabolic encephalopathy, and hepatotoxicity [24]

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Human evidence covers topical use

Polyphenols, widely consumed plant-derived compounds, have demonstrated protective effects on the cardiovascular and cerebrovascular systems, with emerging evidence from preclinical stroke models highlighting their neuroprotective potential, even when administered post-stroke (Parrella et al., 2020)

This inference comes from the observation that Arabidopsis treated with either sublethal cold or H2O2 modifies its calcium signature in response to subsequent cold stress as compared to an untreated control (Knight et al., 1996)

PMID: 258 NilssonAGSundhDBckhedFLorentzonM