Although evidence on sex differences in semaglutides weight loss efficacy remains controversial, several hypotheses have been proposed to explain why females may experience greater weight reduction than males: 1) Pharmacokinetic differences: females often exhibit higher plasma levels of GLP-1 RAs due to lower BW and slower drug clearance compared with males, resulting in increased exposure to the medication and potentially greater weight loss [55,56,57]
Cell Res 31(2):107 Yan Hfa, Zou T, Tuo Q, zhang, Xu S, Li H, Belaidi AA et al (2021) Ferroptosis: mechanisms and links with diseases
p -values below 0.05 ( ), 0.01 (#), and 0.001 () were considered as significant
We found here that agonist trafficking properties, as well as insulin secretion, mirrored -arrestin recruitment propensity, contrasting with some 14,33 (but not all 34 ) previous work suggesting that -arrestins do not impact GLP-1R trafficking 14,34,35 , as well as reports of coupling of GLP-1R to insulin secretion via -arrestin-1 14 (although not -arrestin-2 60 )
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First edition edn, (August Hirschwald, 1858)
