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If you've plateaued on semaglutide, switching to tirzepatide offers a fresh biochemical stimulus

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It helps protect your brain and cells from oxidative stress, a key driver of cellular ageing and age-related changes in memory and thinking, while supporting detoxification, energy production and overall resilience

3.5 HHcy in PCOS Preliminary investigations in observational and randomized controlled trials have indicated that women with PCOS exhibit higher serum homocysteine (Hcy) levels, along with higher levels of markers of CVDs, such as hs-CRP, soluble CD40 ligand (sCD40L), and asymmetric dimethylarginine (ADMA) than did healthy controls (211, 212)

For glycaemic control, it should not be started if your eGFR is below 60 mL/min/1.73m, and it must be stopped if eGFR falls persistently below 30 mL/min/1.73m