Systemic factors like osteoporosis [882], vitamin D deficiency, hypertension, diabetes or cerebrovascular diseases [883] can also contribute to the severity of this disease
This allows your body to adjust to the medication, significantly reducing the risk of severe nausea
This translates to roughly 30 million people taking the most popular GLP-1s for weight loss and to treat Type 2 diabetes, or to reduce their risk of heart disease and stroke
If a patient had both obesity and type 2 diabetes, their GLP-1 prescription might still be covered under the diabetes diagnosis, though many plans implemented stricter documentation requirements to verify the primary treatment purpose
Conversely, people who already present with high anhedonia, for instance, in the context of a depressive illness, may see their symptoms worsening when on GLP-1RAswhich could elucidate some of the studies reporting negative effects associated with these medications in mood and anxiety disorders
Muscle Loss While research is still underway, initial research supports that up to 40 percent of weight lost on these medications could be lean mass
