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Maximum Effect All pharmacologic responses must have a maximum effect (E max )

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Introduction Neonatal hypoxic-ischemic brain damage (HIBD), which is caused by perinatal asphyxia, is a primary etiology for acute neonatal mortality and long-term infant neurological dysfunction ( Endogenous neurogenesis is the process by which neural stem cells (NSCs) undergo symmetric and asymmetric divisions, after which they proliferate and subsequently differentiate into directed progenitor cells that gradually migrate to functional brain areas while undergoing uninterrupted plastic changes and establishing synaptic connections to produce neurological functions (Figure 1)

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