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Metformin has been widely studied for its ability to improve insulin sensitivity and support overall metabolic health
Jeppesen PB, Sanguinetti EL, Buchman A, Howard L, Scolapio JS, Ziegler TR, et al
Lancet 2020;395:16078
The three main problems in relation to treatment with insulin secretagogues are Hypoglycemia Weight gain Cardiovascular risk (an open discussion to date) Contraindications for treatment with insulin secretagogues are as follows: Type 1 diabetes, pregnancy, major surgeries, infections, severe trauma, allergy predisposition, and severe hypoglycemia risks (Table 10.5)
The synergistic action of these peptides allows for broader insight into biological repair pathways and cellular communication
doi: 10.1016/j.ydbio.2014.04.001
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